Radioactive installation platform

The Radioactivity Unit provides groups with specific research laboratories in which to work with radioactive isotopes in liquid form.

These areas are fully equipped and adapted for the handling of radioactive material and apply optimum measures for the safety and radioprotection of staff and the environment.

This area has been authorized by the nuclear safety authority and its staff supervise compliance with the corresponding laws, guidelines and regulations

Common spaces platform

ESU -Experimental surgery unit

Animal surgery unit

USIC- Clinical research support unit

The Clinical Research Support Unit is located on the 13th floor of the Maternal and Child Health Area, at the Vall d’Hebron University Hospital, and consists of two centrally coordinated areas:

  1. The Health Department: provides healthcare support for the development of clinical research in Vall d’Hebron, and offers medical offices to users.
  2. The Management Area: its main function is to provide support in terms of ethics, methodology, regulations and management in conducting clinical research within the Vall d’Hebron, and is part of the SCReN Platform (Spanish Network of ‘Clinical Research) of the Institute of Health Carlos III.

ARO – University research organization

The Vall D’Hebron Research Institute created in 2014 the University Research Organization (ARO) platform with the aim of helping researchers and sponsors to develop clinical research in Vall of Hebron.

The ARO platform offers a complete package on how to manage, from start to finish, the services that are needed to conduct clinical trials and studies. Thanks to its multidisciplinary team, this service can work as a complete contract research organization (CRO) service in clinical trials from phase I to IV within a wide range of possibilities. It also provides advice to the set of researchers and trial sponsors on how to achieve the best experimental design and organizational options to maximize resources.

With the collaboration of other VHIR services, the ARO also participates in other aspects that help the development of research projects.

Mass spectrometry and proteomics

Modern proteomic tools are essential for understanding biological issues. The basic installation of mass spectrometry and proteomics (MSPCF) offers IRB Barcelona researchers and external users a series of techniques based on mass spectrometry (MS) and proteomics that can help improve the their knowledge of diseases, pathways, targets, and the effects of drugs. Develops and implements a wide range of methodologies based on mass spectrometry and applies them to various topics in structural biology, biochemistry, cell biology and, in clinics, in collaboration with IRB research groups and external researchers. . . Currently, the facility offers state-of-the-art applications in quantitative proteomics (differential expression protein analysis using targeted, multiplexing, and unlabeled strategies), high-performance post-translational modification (PTM) analysis, protein, structural MS ((biotinylation).-MS, crosslinking-MS, native MS; study of protein structure, protein complexes and their dynamic interactions) and high-throughput top-down proteomics (which characterizes intact proteins , i.e. proteoforms).

The facility has extensive experience in proteomic analysis in all its approaches (e.g., intact proteins, classical proteomics, data interpretation, and analysis of large data sets) and provides knowledge about proteomics to the scientific community. Non-covalent protein-protein and protein-ligand interactions are also studied by MS and ion-coupled mobility in MS (IM / MS) in order to delve into the mechanisms of action of these proteins in biological processes.

Mutant mouse

The facility was created in 2007. Our primary function is to generate genetically modified mouse models for users within IRB Barcelona. We are able to offer a comprehensive service for the generation of genetically altered mice including:

  • Design of recombinant DNA molecules for genetic modification.
  • Help with cloning protocols and reagents required to generate gene targeting and transgenic vectors.
  • All cell-culture required for gene targeting in mouse embryonic stem (ES) cells, including expansion, transfection, drug selection, colony picking and colony expansion.
  • Microinjection of DNA or ES cells into pre-implantation stage embryos.
  • Electroporation of DNA/mRNA/proteins into pre-implantation stage embryos.
  • Transfer of manipulated embryos into pseudo-pregnant foster mice.
  • Subsequent processing of pups born to pseudopregnant fosters.

Biostatistics / Bioinformatics

The mission of the Biostatistics / Bioinformatics Unit is to carry out collaborative research and offer consultation and quantitative research resources to all IRB Barcelona research groups.

We help scientists by offering consulting services both in the short and long term in the following areas:

  • Experimental design: sample size, study design, statistical methodology planning
  • Data analysis: clinical or biomedical databases, genomics data
  • Help with statistical methodology in own or other people’s research
  • Software: help in the use of software, software development to meet the special needs of data analysis or study design
  • Methodological research is carried out and resources are developed in all the areas mentioned.

IRSP Clean room platform

Clinical research unit

La USIC està situada a la planta 13 de l’Àrea Maternoinfantil (AMI) de l’HUVH i posa a disposició de la investigació clínica els següents serveis i espais: 7 consultoris totalment equipats pel seguiment i exploració dels pacients inclosos en estudis clínics, sala per a extraccions o infusió de medicació, un laboratori pel tractament i conservació de mostres clíniques, un arxiu per a la documentació de l’estudi, i espais per a reunions, monitoritzacions i/o auditories; així mateix dona suport d’infermeria de recerca per a les extracció, processament i gestió de mostres biològiques, i altres proves complementàries.

CERCA - Ginys