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High Biocontainment Unit – Centre de Recerca en Sanitat Animal

GINYS-IRTA-002
Xavier Abad
Cap de la Unitat d’Alta Biocontenció i Laboratoris NBS2 de l’IRTA-CReSA
xavier.abad@irta.cat | 934674040 | ORCID |
FACILITY WEBSITE
IRTA CReSA
CReSA Building. Campus UAB. 08193 Bellaterra
Tel. 93. 467 40 40 (Ext. 1708)
The High Biocontainment Unit facilities at IRTA-CReSA are suitable for working with pathogens of hazard group 3 (according to RD 664/97) and a wide range of animal models (from mice to ruminants, but also all kind of birds). IRTA-CReSA offers the possibility of using both laboratory and animal facilities to perform studies (in a 1500 m2 working area inside a facility accounting with 4500 m2).
  • Technologically advanced facilities to carry out studies with pathogenic agents that require High Biocontainment (also labeled as Animal Biosafety Level 3 (ABSL3) o Biosafety Level 3 Agriculture (BSL3-Ag) measures for their handling.
  • Secure management of high-hazardous infectious agents including airtight isolation systems, negative pressure gradients, absolute air filtration and treatment of all generated liquid and solid wastes.
  • The ABSL3 facility comprises working spaces dedicated to laboratories and animal facilities to work with small and large animals.
  • Experiments are performed following strict ethical and biosafety regulations, providing as much care and animal welfare as possible.
The High Biocontainment Unit at IRTA-CReSA is one of the two nodes of the ICTS High Biosafety Laboratory Network (RLASB).

Services

In
this link you will find the IRTA-CReSA’s services portfolio.

Equipment

High Biocontainment Unit (4,500 m²):  laboratories in High Biocontainment and 13 independent experimental boxes suitable for housing farm animals (pigs, poultry, cattle, sheep, goats, and rabbits), as well as wild animals (goats, birds of prey, deer,chamois, alpacas, llamas, dromedaries, etc.) and laboratory animals (rats, mice, hamsters, etc.). It also includes an insectarium which allows to work with autochthonous but also exotic species. 

Staff

Cap del Programa de Sanitat Animal de l’IRTA-CReSA
Natàlia Majó | natalia.majo@irta.cat | 934674040 | ORCID
Cap de la Unitat d’Alta Biocontenció i Laboratoris NBS2 de l’IRTA-CReSA
Xavier Abad | xavier.abad@irta.cat | 934674040 | ORCID

Projects

Title: BROILERNET: Xarxa d’Innovació en pràctica i ciència en producció en avícola
Reference: https://broilernet.eu
Funding Organism: EU
Status: Executing
Title: COLIBIO: Desxifrant les interaccions Campylobacter coli-hoste per al desenvolupament d'eines eficaces de control en avicultura
Funding Organism: MICINN
Status: Executing
Title: DECIDE (Fase2) Control i priorització de malalties animals contagioses no regulades per la UE
Reference: https://decideproject.eu
Funding Organism: UE
Status: Select
Title: EPIVINF (Fase 2) Regulació epigenètica de factors hostes en infeccions víriques
Reference: https://cordis.europa.eu/project/id/101057548/es
Funding Organism: UE
Status: Executing
Title: FAECAL-PHAGE: El trasplantament de la microbiota fecal com a alternativa als antimicrobians per a la prevenció de malalties entèriques causades per Escherichia coli i Salmonella en porcí
Funding Organism: MICINN
Status: Executing
Title: FARMBANK: Granja in vitro: desenvolupament del primer biobanc de organoides d'animals de granja com a alternativa als experiments amb animals en la recerca de malalties infeccions
Funding Organism: MICINN
Status: Executing
Title: ISIDORe: Serveis integrats per a la investigació de brots de malalties infeccioses
Reference: https://isidore-project.eu
Funding Organism: UE
Status: Executing
Title: OFFPol: Desenvolupament d'un test ràpid de pronòstic i diagnòstic de la poliserositis porcina per a ser realitzat en granja
Funding Organism: MICINN
Status: Executing
Title: ZooPrion: Desenvolupament de models innovadors de malalties priòniques i estudi de la patobiologia de prions sintètics en ratolins transgènics y hostes poc comuns.
Funding Organism: MICINN
Status: Executing
Title: EpiWestNileMosq - Determinació del paper de mosquits vectors i altres factors en la transmissió del virus del Nil Occidental
Funding Organism: MICINN
Status: Executing
Title: INFLUOMA - Investigant els mecanismes moleculars de l'evolució de la infecció amb virus d'influença aviària en les aus mitjançant una aproximació multi-òmica
Funding Organism: MICINN
Status: Executing
Title: Plataforma in vitro lab NBS3 CReSA - Plataforma per a la monitorització in vitro, in vivo i ex vivo d'infeccions en alta biocontención (NBS3)
Funding Organism: MICINN
Status: Executing
Title: Desxiframent infecció severa del SARS-CoV-2 - Desxiframent del paper de la resposta humoral en el desenvolupament de la infecció severa del SARS-CoV-2 durant la infecció natural i després de la vacunació
Funding Organism: Fundació La Marató
Status: Executing
Title: PORCOPROTECT: Resposta immunitària innata enfront de coronavirus porcins entèrics. Modulació de la resposta d'interferó de tipus III per a la millora de la protecció a nivell mucosal.
Funding Organism: MICINN
Status: Executing

Publications

Immunogenicity and Protection against Mycobacterium caprae Challenge in Goats Vaccinated with BCG and Revaccinated after One Year
Arrieta-Villegas, C., Vidal, E., Martin, M., Verdes, J., Moll, X., Espada, Y., Singh, M., Villarreal-Ramos, B., Domingo, M., & de Val, B. P.
Vaccines, 8(4), 16, Article 751. (2020)
DOI: 10.3390/vaccines8040751
Animal models for COVID-19
Muñoz-Fontela, C., Dowling, W. E., Funnell, S. G. P., Gsell, P. S., Riveros-Balta, A. X., Albrecht, R. A., Andersen, H., Baric, R. S., Carroll, M. W., Cavaleri, M., Qin, C., Crozier, I., Dallmeier, K., de Waal, L., de Wit, E., Delang, L., Dohm, E., Duprex, W. P., Falzarano, D., Finch, C. L., Frieman, M. B., Graham, B. S., Gralinski, L. E., Guilfoyle, K., Haagmans, B. L., Hamilton, G. A., Hartman, A. L., Herfst, S., Kaptein, S. J. F., Klimstra, W. B., Knezevic, I., Krause, P. R., Kuhn, J. H., Le Grand, R., Lewis, M. G., Liu, W. C., Maisonnasse, P., McElroy, A. K., Munster, V., Oreshkova, N., Rasmussen, A. L., Rocha-Pereira, J., Rockx, B., Rodriguez, E., Rogers, T. F., Salguero, F. J., Schotsaert, M., Stittelaar, K. J., Thibaut, H. J., Tseng, C. T., Vergara-Alert, J., Beer, M., Brasel, T., Chan, J. F. W., Garcia-Sastre, A., Neyts, J., Perlman, S., Reed, D. S., Richt, J. A., Roy, C. J., Segales, J., Vasan, S. S., Henao-Restrepo, A. M., & Barouch, D. H.
Nature, 586(7830), 509-515 (2020)
DOI: 10.1038/s41586-020-2787-6
Strategies for Feeding Unweaned Dairy Beef Cattle to Improve Their Health
Devant, M., & Marti, S.
Animals, 10(10), 20, Article 1908 (2020)
DOI: 10.3390/ani10101908
Assessing the role of livestock and sympatric wild ruminants in spreading antimicrobial resistant Campylobacter and Salmonella in alpine ecosystems
Espunyes, J., Cabezón, O., Dias-Alves, A. et al.
BMC Vet Res 17, 79 (2021)
DOI: 10.1186/s12917-021-02784-2
Chicken liver is a potential reservoir of bacteriophages and phage-derived particles containing antibiotic resistance genes
Pedro Blanco-Picazo, Clara Gómez-Gómez, Sergi Aguiló-Castillo, Dietmar Fernández-Orth, Marta Cerdà-Cuéllar, Maite Muniesa, Lorena Rodríguez-Rubio
Microbial Biotechnology(2022)15(9), 2464–2475 (April 2022)
DOI: 10.1111/1751-7915.14056
West Nile Virus Lineage 2 Spreads Westwards in Europe and Overwinters in North-Eastern Spain (2017–2020)
Aguilera-Sepúlveda, P.; Napp, S.; Llorente, F.; Solano-Manrique, C.; Molina-López, R.; Obón, E.; Solé, A.; Jiménez-Clavero, M.Á.; Fernández-Pinero, J.; Busquets, N.
Viruses 2022, 14, 569 (March 2022)
DOI: 10.3390/v14030569
Hotspot of Crimean-Congo Hemorrhagic Fever Virus Seropositivity in Wildlife, Northeastern Spain
Espunyes J, Cabezón O, Pailler-García L, Dias-Alves A, Lobato-Bailón L, Marco I, et al.
Emerging Infectious Diseases. 2021;27(9):2480-2484 (September 2021)
DOI: 10.3201/eid2709.211105
The FlagT4G Vaccine Confers a Strong and Regulated Immunity and Early Virological Protection against Classical Swine Fever
Bohórquez, J.A.; Wang, M.; Díaz, I.; Alberch, M.; Pérez-Simó, M.; Rosell, R.; Gladue, D.P.; Borca, M.V.; Ganges, L.
Viruses 2022, 14, 1954 (September 2022)
DOI: 10.3390/v14091954
Clearance and persistence of Escherichia coli in the freshwater mussel Unio mancus
Campos, M.; Lobato-Bailón, Lourdes; Merciai, R.; [et al.].
Scientific reports (Nature Publishing Group), Vol. 12 (july 2022)
DOI: 10.1038/s41598-022-16491-x
Evolution of Swine Influenza Virus H3N2 in Vaccinated and Nonvaccinated Pigs after Previous Natural H1N1 Infection
López-Valiñas, Álvaro; Baioni, Laura; Córdoba, Lorena; [et al.].
Viruses, Vol. 14 (september 2022)
DOI: 10.3390/v14092008
Rapid SARS-CoV-2 Inactivation in a Simulated Hospital Room Using a Mobile and Autonomous Robot Emitting Ultraviolet-C Light
Lorca-Oró, Cristina; Vila, Jordi; Pleguezuelos, Patricia; [et al.].
The Journal of Infectious Diseases, Vol. 225 (november 2021)
DOI: 10.1093/infdis/jiab551
Piglet innate immune response to Streptococcus suis colonization is modulated by the virulence of the strain
Neila-Ibáñez, Carlos María; Brogaard, Louise; Pailler-García, Lola; [et al.]
Veterinary research, Vol. 52 (december 2021)
DOI: 10.1186/s13567-021-01013-w
Immune Responses to Pandemic H1N1 Influenza Virus Infection in Pigs Vaccinated with a Conserved Hemagglutinin HA1 Peptide Adjuvanted with CAF ® 01 or CDA
López-Serrano, Sergi; Córdoba, Lorena; Pérez-Maillo, Mónica; [et al.]
Vaccines, Vol. 9 (july 2021)
DOI: 10.3390/vaccines9070751
Cross-protection against African swine fever virus upon intranasal vaccination is associated with an adaptive-innate immune crosstalk
Bosch Camós, Laia; Alonso, Uxía; Esteve-Codina, Anna; [et al.].
PLoS pathogens, Vol. 18 (november 2022)
DOI: 10.1371/journal.ppat.1010931
Agreement and differential use of laboratory methods for the detection and quantification of SARS-CoV-2 in experimentally infected animals
Usai, Carla; Pailler-García, Lola; Lorca-Oró, Cristina; [et al.].
Frontiers in microbiology, Vol. 13 (november 2022)
DOI: 10.3389/fmicb.2022.1016201
Dual Host and Pathogen RNA-Seq Analysis Unravels Chicken Genes Potentially Involved in Resistance to Highly Pathogenic Avian Influenza Virus Infection
Perlas, Albert; Argilaguet, Jordi; Bertran, Kateri; [et al.].
Frontiers in immunology, Vol. 13 (may 2022)
DOI: 10.3389/fimmu.2022.939849
A novel optical sensor system for the automatic classification of mosquitoes by genus and sex with high levels of accuracy
González-Pérez, María I.; Faulhaber, Bastian; Williams, Mark; [et al.].
Parasites & vectors, Vol. 15 (june 2022)
DOI: 10.1186/s13071-022-05324-5
Potential of Oral Nanoparticles Containing Cytokines as Intestinal Mucosal Immunostimulants in Pigs: A Pilot Study
López-Cano, Adrià; Bach, Àlex; López-Serrano, Sergi; [et al.].
Animals, Vol. 12 (april 2022)
DOI: 10.3390/ani12091075
Widespread Circulation of Flaviviruses in Horses and Birds in Northeastern Spain (Catalonia) between 2010 and 2019
Napp Avelli, Sebastián; Llorente, Francisco; Beck, Cécile; [et al.]
Viruses, Vol. 13 (november 2021)
DOI: 10.3390/v13122404
A proof-of-concept study to investgate the efficacy of heat-inactvated autovaccines in Mycobacterium caprae experimentally challenged goats
Melgarejo, Cristan; Planas Padrós, Carles; Cobos Arnalot, Àlex; [et al.].
Scientfic reports (Nature Publishing Group), Vol. 12 (december 2022)
DOI: 10.1038/s41598-022-26683-0
Bona fide atypical scrapie faithfully reproduced for the first time in a rodent model
Vidal Barba, Enric; Sánchez-Martín, Manuel A.; Eraña, Hasier; [et al.]
Acta neuropathologica communications, Vol. 10 (december 2022)
DOI: 10.1186/s40478-022-01477-7
Review on the methodology to assess respiratory tract lesions in pigs and their production impact
Maes, Dominiek; Sibila, Marina; Pieters, Maria; [et al.].
Veterinary research, Vol. 54 (february 2023)
DOI: 10.1186/s13567-023-01136-2

INSTITUTE

IRTA - Institut de Recerca i Tecnologia Agroalimentàries

Torre Marimon

08140 Caldes de Montbui http://www.irta.cat/

DOMAINS RIS3CAT

  • Food system
  • Education and knowledge generation system
  • Industrial system
  • Socio-sanitary system

CATEGORIES

  • STABLES AND ANIMAL EXPERIMENTATION CENTERS
    • Specialized animal experimentation
  • TECHNOLOGICAL EQUIPMENT
    • Other specializated laboratories

RATES AND ACCESS

Availability Level: Medium
Access Procedures:
Open

QUALITY CONTROL

Biosafety Level 3 (or NBS3)
It is already considered a high level of containment, it is found in some clinical and diagnostic laboratories, and some university and government research laboratories, in which work is done with exotic agents or that can cause serious damage and potentially fatal as a result of inhalation or exposure to them (some haemorrhagic fever viruses, but not filoviruses, many arboviruses and bacteria with Francisella tularensis, Coxiella burnetii, SARS-CoV-2 (COVID-19), etc.)
Website link
Status: Active
Biosafety Level 2 (or NBS2)
Moderate risk agents are handled for staff and the environment, so they are the most common in clinical, hospital and academic research.
Website link
Status: Active
Biosafety Level (or NBS1)
We work with agents who present a minimum danger to the laboratory staff and to the environment. Access to the laboratory is not restricted and the work is carried out regularly in standard laboratory benches, open work tables
Website link
Status: Active
GMO Type 3 – Moderate Risk
USE CONFINED WITH GMO TYPE 3 (Moderate Risk) IN SPAIN In accordance with the provisions of article 5 of Law 9/2003, confined use is understood to be any activity for which the genetic material of an organism is modified or for which it, as modified, is cultivated, stored, used. , transport, destruction or disposal, provided that containment measures are used in carrying out these activities, in order to limit contact with the population and the environment.
Website link
Status: Active
Register of Breeding Centers, Suppliers and Users of Experimental Animals
Centers that use animals for experimentation or other scientific purposes must be registered in the Register of Breeding Centers, Suppliers and Users of Experimental Animals.
Website link
Status: Active
HRS4R
Human Resource Strategy for Researchers It supports research institutions and funding organizations in implementing the Charter and Code in their policies and practices. The implementation of the Charter and Code principles by research institutions makes them more attractive to researchers looking for a new employer or host for their research project..
Website link
Status: Active
GLP (or BLP) Practice
Research laboratories with a certificate of compliance with good laboratory practices - ENAC Good laboratory practice (GLP) The principles of good laboratory practice (GLP) are used to perform tests to obtain data on the properties and hazards for humans, animals and the environment of any chemical..
Website link
Status: Active
ISO 17025 – Testingand Calibration Laboratories
ISO / IEC 17025 allows laboratories to demonstrate that they operate competently and generate valid results, thus promoting confidence in their work both nationally and worldwide.
Website link
Status: Active
ISO 9001 – Quality Management
ISO 9001 sets out the criteria for a quality management system. This standard is based on a number of quality management principles that include a strong customer focus, motivation and involvement of senior management, process focus, and continuous improvement. The use of the ISO 9001 standard helps to ensure that customers receive consistent and good quality products and services, which in turn brings many business benefits.
Website link
Status: Active

FACILITIES NETWORKS

RLASB – Biological Safety Laboratory Network (ICTS)

The Network of High Biological Safety Laboratories (RLASB) is a Singular Scientific and Technological Infrastructure (ICTS) of High Biological Safety Laboratories that offers the possibility of using integrated laboratory and animal services, dedicated exclusively to working with infectious agents. requiring high biological safety conditions to handle it. The RLASB is a distributed ICTS infrastructure made up of two nodes: -High Biological Safety Laboratories (NBC3) of the INIA-CISA Animal Health Research Center -High Biological Safety Laboratories (NBC3) of the IRTA Animal Health Research Center -CReSA

Network link
Reach: Spain
Status: Active
PRC page
CERCA - Ginys