Magnetic resonance imaging
GINYS-IDIBAPS-004
Emma Muñoz-Moreno
Cap de la plataforma
Magnetic resonance imaging (MRI) allows for
visualization of organs and tissue in a non-invasive way, as well as its
the characterization of their anatomical and functional properties. The
IDIBAPS Magnetic Resonance Imaging Core Facility has two scanners for MR acquisition both in humans and in small animal o tissue samples. Besides, the facilty has an image laboratory
with specific computer equipment and highly qualified staff specialized
in research and development of analysis algorithms adapted to each
project requirements. Together with image acquisition and analysis, the
facility provides advisory service during the whole project: from project conception to the results discussion and interpretation.
Services
Magnetic resonance image acquisition in human and small animal. Among the image modalities provided by the facility, we can highlight:
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Anatomical imaging
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Diffusion imaging for microstructural and/or brain connectivity network analysis.
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Resting-state and task-based functional imaging to identify patterns of cerebral activity.
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Perfusion imaging to characterized blood flow in tissues.
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Magnetic resonance spectroscopy, which allows for metabolite quantification.
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Angiography to visualize the vasculature.
Magnetic resonance imaging in tissue samples, including:
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High-resolution anatomical imaging.
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Diffusion imaging for microstructure analysis and visualization.
Image processing and analysis. The image laboratory provides image analysis applying different techniques, including both standard methodologies and specific algorithms developed to fit the project requirements. Among the provided analysis, we can highlight:
- Volumetric analysis: volumes of regions of interest, cortical thickness, etc..
- Metabolite quantification
- Anatomical and/or functional brain connectivity analysis.
- Identification of brain networks associated to specific tasks.
- Quantification of blood perfusion in the tissues.
- 3D shape analysis for anatomical structures.
- Radiomics, artificial intelligence based analysis.
Equipment
Clinical research unit (3 Tesla):
- MR scanner for human imaging (3 Tesla Siemens Prisma Fit)
- Visual and auditive stimulus presentation systems to perform functional MRI studies (Presentation, VisuaStim Digital)
- Screen for visual stimulus projection.
- Remote control to register the subject response in task-based functional MRI.
Experimental imaging unit (7 Tesla)
- MR scanner for imaging small animal or tissue samples (7
Tesla Bruker Biospec 70/30) equiped with specific coils for mice and rat imaging. - Anesthesia system by inhalation
- Animal physiology monitoring system.
Image analysis and processing laboratory:
- 2 workstation and 16 PCs.
- Image analysis software: MatLab, LCModel, Freesurfer, FSL, itkSNAP, Synthetic MR, RAIM Alma
Staff
Àngels Calvet | CALVETI@recerca.clinic.cat
Jose Carlos Pariente Zorrilla | pariente@recerca.clinic.cat
Marta Peña González | penai@recerca.clinic.cat
Alejandro Hinojosa | ahinojosa@recerca.clinic.cat
César Garrido | cgarrido@clinic.cat
Sandra Pineda | pineda@clinic.cat
Publications
Brain structural trajectories in youth at familial risk for schizophrenia or bipolar disorder according to development of psychosis spectrum symptoms
Child Psychol. Psychiatr., 62: 780-789
Child Psychol. Psychiatr., 62: 780-789
Prognostic significance of infarct size and location: the case of insular stroke
Scientific Reports (2018), 8: 9498
Scientific Reports (2018), 8: 9498
Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study
Brain (2018) 141(2), 391–408
Brain (2018) 141(2), 391–408
M2 cortex-dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington’s disease
eLife 9:e57017.
eLife 9:e57017.
Brain connectivity during Alzheimer’s disease progression and its cognitive impact in a transgenic rat model
Network Neuroscience (2020) 4 (2): 397–415.
Network Neuroscience (2020) 4 (2): 397–415.