HTE - High throughput experimentation
GINYS-ICIQ-007
Dr. Xisco Caldentey
Manager
The High Throughput Experimentation (HTE) laboratory is dedicated to running a large number of reactions and analyzing them in a short period of time with the intention of accelerating the discovery processes; discovery of new reactions, new products or new reaction conditions. The facility is configured to run different types of reactions in 24- or 96-well plates, including those that are air-sensitive, reactions with reactive gases, photochemical reactions or reactions under pressure conditions. In addition, the Laboratory has a large number of reagents, solvents, metals and ligands to carry out the reactions. Regarding the analysis of the reactions, the laboratory is equipped with state-of-the-art chromatographs.
Services
• Rapidly
examine arrays of conditions (catalysts, reagents, solvents…) with minimal
material consumption
examine arrays of conditions (catalysts, reagents, solvents…) with minimal
material consumption
•
Rapid ligand screening
Rapid ligand screening
•
Process optimization
Process optimization
• Optimize
individual steps in a synthesis
individual steps in a synthesis
•
Discovery of new methodology
Discovery of new methodology
•
Generate molecular diversity
Generate molecular diversity
• Late-stage
functionalization of an active ingredient
functionalization of an active ingredient
•
Structure–activity relationship
Structure–activity relationship
Equipment
- Train of glove boxes for storing chemicals and preparing sensitive reactions under inert atmosphere
- Pipettes: single and multiple channel
- Aluminum reaction blocks with ANSI/SLAS format
- Photochemical reactors
- Pressure reactors
- Stirrers and shakers
- Heating/cooling devices ANSI/SLAS format
Automatic solids dispensing system
- UHPLC-MS/DAD (Waters)
- SFC-DAD/MS (Waters)
- GC-MS/FID (Agilent)
- Large capacity auto samplers on all chromatographs
- Wide range of chromatographic columns available, including chiral
